Xanthones as an Anti Inflammatory Medicine

In 1980 the Indian Journal of Pharmacology did a study on Xanthones and one of there findings was.

“All the xanthones exhibited anti inflammatory activity both by intraperitoneal and oral routes in rats as tested by carrageenin induced hind paw oedema, cotton pellet granuloma and granuloma pouch techniques, in normal and adrenalectomised rats.”

YR:1980-VL12-ISS.3 PG 181-191

Effects of xanthones, from mangosteen, in human leukemia cell lines.

In August of 2003 the Gifu International Institute of Biotechnology examined the effects of six xanthones from the pericarps of the mangosteen fruit, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60.

All xanthones displayed growth inhibitory effects.

Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.

PMID: 12932141 Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan.

Antimycobacterial activity of prenylated xanthones from the fruits of mangosteen.

Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of mangosteen, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis.

Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9.

Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana (mangosteen) and their synthetic derivatives.

The antifungal activity of several xanthones isolated from the fruit hulls of mangosteen and some derivatives of mangostin against three phytopathogenic fungi, Fusarium oxysporum vasinfectum, Alternaria tenuis, and Dreschlera oryzae, has been evaluated. The natural xanthones from mangosteen showed good inhibitory activity against the three fungi.

J Nat Prod. 1997 May;60(5):519-24.

source : www.mangosteeneffect.com